![]() Now of course, you get CNS depression directly from alcohol. Concentration is proportional to glucose (small) and also because we don't normally have lots of insulin to stimulate it. ![]() INHIBITED by insulin because you'll have more G6P. Takes glucose when it can get it, and hits Vmax quickly. So speed depends on how much glucose is around! Sigmoidal curve cooperativity. Need lots of glucose to reach saturation. Very little glucose causes it to work at max capacity, which is "weak." This is when you're doing gluconeogenesis!! So the liver won't do glycolysis and gluconeogenesis at the same time. So it's only "off" when you have a low blood sugar and a high F6P. ![]() It is affected by INSULIN (actually increases its transcription). Glucokinase is affected by F6P, the next step down the line. Hexokinase is inhibited by G6P, so the cell will stop taking glucose if you already have enough.
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